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Recombinant Human IL-6(Cat. No.:C009)
DS
COA
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Size：
10μg
50μg
500μg
1mg
Count：
-
1
+
Description
Recombinant Human Interleukin-6 is produced by our E.coli expression system and the target gene encoding Val30-Met212 is expressed.
Accession
P05231
Known As
Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2
Mol Mass
20.9 KDa
APMol Mass
20 KDa, reducing conditions
Formulation Description
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 5% Sucorse, 4% Mannitol, 0.05% PS-80, pH7.4.
Endotoxin
< 0.01 EU/µg as determined by LAL test.
Purity-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Bioactivity-Cell Based Assay
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 20-100 pg/ml. (QC verified)
Reconstitution
  • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
  • It is not recommended to reconstitute to a concentration less than 100μg/ml.
  • Dissolve the lyophilized protein in distilled water.
  • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Storage
  • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
  • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
  • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping
  • The product is shipped at ambient temperature.
  • Upon receipt, store it immediately at the temperature listed below.
Background
Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.
仅供科研或生产使用，不可直接应用于人体。
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