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股票简称：近岸蛋白
股票代码：688137
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Recombinant Human Claudin-18.2 (N-8His)(Cat. No.:CR53)
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COA
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Size：
10μg
50μg
500μg
1mg
Count：
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1
+
Description
Recombinant Human CLDN18.2 is produced by our E.coli expression system and the target gene encoding Asp28-Leu76 is expressed with a 8His tag at the N-terminus.
Accession
P56856-2
Known As
Claudin-18; CLDN18
Mol Mass
19.7 KDa
APMol Mass
18 KDa, reducing conditions
Formulation Description
Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 25mM NaCl, 0.1% Triton X-100, 10% glycerol, 0.1mM GSH, 0.01mM GSSG, pH 8.0.
Endotoxin
< 1 EU/µg as determined by LAL test.
Purity-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Storage
  • Store at ≤-70°C, stable for 6 months after receipt.
  • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
  • Please minimize freeze-thaw cycles.
Shipping
  • The product is shipped on dry ice/polar packs.
  • Upon receipt, store it immediately at the temperature listed below.
Background
Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
仅供科研或生产使用，不可直接应用于人体。
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