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Recombinant Human BMP-4(Cat. No.:CR93)
DS
COA
Price：
$213
Size：
10μg
50μg
500μg
1mg
Count：
-
1
+
Information
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Description
Recombinant Human Bone morphogenetic protein 4 is produced by our E.coli expression system and the target gene encoding Ser293-Arg408.
Accession
P12644
Known As
Bone morphogenetic protein 4; BMP-4; BMP4; BMP2B; DVR4
Mol Mass
13.3 KDa
APMol Mass
12-14 KDa, reducing conditions
Formulation Description
Supplied as a 0.2 μm filtered solution of 4mM HCl.
Endotoxin
< 0.01 EU/µg as determined by LAL test.
Purity-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE.
Bioactivity-Cell Based Assay
Recombinant Human BMP-4 induces alkaline phosphatase production in ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 152.7ng/mL(Regularly tested).
Human intestinal organoids (ipsc source) were cultured with Activin A(C687) , BMP-4(CR93) , EGF (C029) , Wnt3a (C22R), Noggin (C028), R-spondin 1 (CX83) and FGF-4 (CR08) . The organoids showed good morphology.
Storage
  • Store at ≤-70°C, stable for 6 months after receipt.
  • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
  • Please minimize freeze-thaw cycles.
Shipping
  • The product is shipped on dry ice/polar packs.
  • Upon receipt, store it immediately at the temperature listed below.
Background
Bone morphogenic protein-4 (BMP-4) is one of nine structurally related BMPs belonging to the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. BMP-4 has important roles as a signalling molecule in embryonic tissues, including the developing central and peripheral nervous system, musculature and skeleton. BMP-4 as well as its receptors and their signal transduction pathways play a crucial role in the control of the differentiation and proliferation of the different cell types that constitute the anterior pituitary.
For Research or Manufacturing Use Only, Not for Use in Diagnostic or Therapeutic Procedures.
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Raw materials for molecular diagnostics