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Home > Product > MPXV A29L Antibody(7B12)
MPXV A29L Antibody(7B12)(Cat. No.:DA130)
DS
COA
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Size：
500μg
1mg
Count：
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1
+
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Troubleshooting
Isotype
Human IgG1
Mol Mass
48.8&24.0 kDa
APMol Mass
(50-58)&(24 -29) kDa, reducing conditions
Formulation Description
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Purity-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE.(QC verified)
Bioactivity-ELISA
Immobilized Recombinant MPXV A29L Protein (110AA)(DRA206) at 2μg/ml (100 μl/well) can bind MPXV A29L Antibody(7B12)(DA130). The ED50 of MPXV A29L Antibody(7B12)(DA130) is 3.79ng/ml.(Regularly tested)
Immobilized Recombinant MPXV A29L Protein (DRA207) at 2μg/ml (100 μl/well) can bind MPXV A29L Antibody(7B12)(DA130). The ED50 of MPXV A29L Antibody(7B12)(DA130) is 2.57ng/ml.(Regularly tested)
Pair recommendations
CAPTURE ANTIBODYDETECTION ANTIBODY
DA131(clone#5C9) DA130(clone#7B12)
Storage
24 months from manufacturing at ≤-20 °C; 1 month, 2 to 8 °C under sterile conditions.
Shipping
The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background
Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. A29L is an intracellular mature virus (IMV) surface envelope protein that is homologous to vaccinia virus (VACV) A27 and is widely conserved in the Poxviridae family. The A27L protein (p14) is a multifunctional protein that has been implicated in virus attachment, virus–cell fusion, cell–cell fusion, plaque size, and the formation of enveloped virions. The involvement of A27 in mature virus (IMV) inhibits the assembly of fusion protein A26. After MVs are endocytosed by vesicles, the acidic endocytic environment activates the dissociation of A26 protein from MVs, resulting in fusion of the viral membrane with the vesicle membrane. A27 interacts with the integral membrane protein A17, and then forms a protein complex with A26 through disulfide bond linkage to anchor the A26 protein to mature virus (MV) particles.
For Research or Manufacturing Use Only, Not for Use in Diagnostic or Therapeutic Procedures.
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Resource Download
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