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Recombinant RABV Glycoprotein(Cat. No.:DRA244)
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COA
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Size：
50μg
500μg
1mg
Count：
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1
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Description
Recombinant RABV (strain SRV9) Glycoprotein is produced by our Mammalian expression system and the target gene encoding Lys20-Tyr459 expressed with a 6His tag at the C-terminus.
Accession
AF499686.2
Known As
Glycoprotein; G protein
Mol Mass
48.9 kDa
APMol Mass
58-70 kDa, reducing conditions
Formulation Description
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Purity-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Purity-SEC-HPLC
Greater than 95% as determined by SEC-HPLC.(QC verified)
Bioactivity Data
1
Storage
  • Reconstituted protein solution should be stored at ≤ -20°C.
  • Stable for at least 24 months when stored as instructed.
Shipping
The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background
Rabies virus (RABV), the etiological agent for the lethal disease of rabies, is a deadly zoonotic pathogen. The RABV glycoprotein (RABV-G) is a key factor mediating virus entry and the major target of neutralizing antibodies. RABV-G has three domains, and the basic-to-acidic pH change results in large domain re-orientations and concomitant domain-linker re-constructions, switching it from a bent hairpin conformation into an extended conformation. The antibody interacts with RABV-G mainly through its heavy chain and binds to a bipartite conformational epitope in the viral protein for neutralization. These structures provide valuable information for vaccine and drug design.
For Research or Manufacturing Use Only, Not for Use in Diagnostic or Therapeutic Procedures.
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Resource Download
Total solution for RNA vaccines drugs research and development
Target Proteins/ Enzymes for Antibody Drug Development