Recombinant Influenza B (B/Yamagata/16/1988) Neuraminidase is produced by our Mammalian expression system and the target gene encoding Leu32-Leu466 is expressed with a 6His tag at N-terminus.

Neuraminidase; NA

55.1 kDa

57-88 kDa, reducing conditions

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.

Influenza B viruses (IBV) co-circulate annually with Influenza A viruses (IAV) around the world, resulting in annual epidemics that cause significant health and social-economic burden. The critical role of the NA in the influenza life cycle makes it a promising target for vaccines and therapeutics. NA is the second dominant glycoprotein on the surface of IAV and IBV. The amount of NA on virion is 5 to 10 fold less than HA. NA is a tetrameric membrane glycoprotein that consists of four identical monomers which include a catalytic head domain, a stalk domain, a transmembrane domain, and a cytoplastic tail. While HA allows viruses to attach and penetrate host cells, NA is crucial for releasing new virions from cell surfaces by cleaving sialic acids and allowing viruses to detach from host cells. NA also plays a significant role in preventing influenza virions from aggregation, therefore promoting virus spread.