Recombinant HSV-1 Envelope Glycoprotein C is produced by our Mammalian expression system and the target gene encoding Glu27-His457 is expressed with a His tag at C-terminus.

Envelope Glycoprotein C; Glycoprotein C; gC

47.2 kDa

75-125 kDa, reducing conditions

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.

Herpes simplex virus (HSV) anterograde transport in neuronal axons is vital, allowing spread from latently infected ganglia to epithelial tissues, where viral progeny are produced in numbers allowing spread to other hosts. The HSV membrane proteins gE/gI and US9 initiate the process of anterograde axonal transport, ensuring that virus particles are transported from the cytoplasm into the most proximal segments of axons. Herpes simplex virus (HSV) glycoprotein C (gC) functions in viral entry and binds to complement component C3b, inhibiting complement-mediated immunity. HSV-1 gC protects the viral envelope glycoproteins essential for entry, including gB, by shielding them from neutralization as a potential mechanism of immune evasion. gC is the principal viral ligand for binding to cell surface heparan sulfate proteoglycans, and gC is one of the main targets for CD4 T-lymphocyte cytotoxicity in human epidermal keratinocytes.