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Recombinant Human GM-CSF(Cat. No.:GMP-CC79)
DS
COA
Price：
Size：
50μg
500μg
1mg
Count：
-
1
+
Datasheet
GMP-CC79-EN.pdf
Accession
P04141
Shipping
Lyophilized product in powder form, 2-8℃ temperature required for transport
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Protein Species
Human
Source
Human Cells
Protein Expression Range
Ala18-Glu144
Tag
C-6His
Abbreviation
GM-CSF
Key Words
Granulocyte-Macrophage Colony-Stimulating FactorGM-CSFColony-Stimulating FactorCSFMolgramostinSargramostimCSF2GMCSF
Language Code
English
Priority Level
104
Description
  • GM-CSF stimulates the colony formation of neutrophils and macrophages in vitro and serves for promoting the proliferation and development of early erythroid megakaryocytes and eosinophil progenitor cells. It is one of the earliest cytokines discovered to have an effect on dendritic cells (DCs).
  • During the culture of DC, GM-CSF can promote the differentiation of monocytes into large macrophage cells, as well as the expression of MHC class II molecules on the cell surface, thus enhancing the antigen presentation function of cells. Also, GM-CSF promotes the survival of DCs. GM-CSF can activate the immune response in a variety of tumor models. The antitumor activity of GM-CSF comes from its biological function of activating macrophages and DCs. Early studies showed that CD4+ and CD8+ T cells are involved in anti-tumor immunity activated by GM-CSF. Recent studies have shown that NKT plays an important role in the antitumor activity involving GM-CSF.
  • Recombinant Human GM-CSF is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.
Quality Control
ItemStandard
AppearanceWhite porosity
ReconstitutionTotally dissolve in stated time
Visible particleConform to ChP
pH value6.9–7.9
Purity≥ 95%
Bioactivity≥ 2.0×107 IU/mg
Endotoxin< 10 EU/mg
Host protein≤ 0.005%
Exogenous DNA residue≤ 100 pg/mg
Mycoplasma testNegative
Sterility testConform to ChP
Storage
Storage at -20℃, expiration date labeled on bottle.
First Classification
Gene and Cell Therapy
URLClassification
Gene and Cell Therapy,,GMP Grade Cytokines,,N/A
Catalog Number
GMP-CC79
Usage
  • In-vitro cultivation of various types of cell.
  • During the culture of DCs, the combination of IL-4 and GM-CSF (Cat. No.: GMP-CC79) directionally differentiate monocytes into immature DCs. The DCs cultured this way have strong antigen uptake and processing abilities but weak antigen presentation abilities. Therefore, sequentially use with TNF-alpha (Cat. No.: GMP-C008) to promote DCs maturing.
Second Classification
GMP Grade Cytokines
Product Name
Recombinant Human GM-CSF
Highest Abbreviation
Human GM-CSF
Recommendations
  • （1）Make sure the product properly stored and none expired before using.
  • （2）Please use water for injection for reconstitution, to a concentration > 100 μg/ml.
  • （3）Sterile condition without pyrogen is required for reconstitution, re-aliquoting, dilution.
  • （4）After reconstitution, aliquoted solution vials should be stored at -70°C and minimize freeze-thaw cycles preventing denaturation of protein.
Size/Price
50μg/$375500μg/Inquiry1mg/Inquiry
Formulation
0
Product Status
1
仅供科研或生产使用，不可直接应用于人体。
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